Colon Cancer Essay -- Biology Biological Medical Essays

Colon Cancer Disease Name: Colon Cancer Chromosome Number: #2 Locus Designation: 2p16 In the summer of 1993 researchers discovered a gene, known as MSH2, is lacking within colon cells. The MSH2 genes main function is to detect and correct small mutations that occur during cell division. The cause of colon cancer arises when this gene does not provide this protection to colon cells. This lack of protection causes multiple mutations within the colon cells until they become cancerous. Only about 6% of all colorectal cancer is said to be hereditary. Sporadic, or non hereditary colorectal cancer, makes up the other 94%. Hereditary colorectal cancer is made up of two syndromes- HNPCC (Hereditary Non Polyposis Colorectal Cancer) and FAP (Familial Adenomatous Polyposis). HNPCC is estimated to be 5% of the total hereditary colorectal cancer. HNPCC is a autosomal dominant disease, meaning that children have a 50% chance of inheriting the genetic trait from one of the parents being autosomally dominant. The parents who are autosomal dominant have a defect in their mis- match genes which identify and repair somatic mutations in DNA during cell division. Four genes have been identified as carrying this mutation; hMSH2, hMHL1, hPMS1, and hPMS2. ( h standing for hereditary) FAP constitutes only about 0.5 % of all hereditary colorectal cancer. It is also an autosomal dominant disease. Patients with FAP have a 100% risk of getting colorectal cancer, but it can be avoided. FAP is caused by a mutation in the APC gene on chromosome 5. The APC gene is able to be detected by a blood test. A study done in 1994 revealed that since the time the APC gene was identified 100 different mutations leading to st... ...er, making it the third leading cancer caused death rate. The main objective of doctors who deal with patients with colorectal cancer is not to cure, but actually to reduce mortality. With recent advancements research are finding new links to the effects of colorectal cancer genetically and physically. Works Cited: Caspari, Reiner. 3/12/94. Familial Adenomatous Polyposis: Mutations at Codon 1309 and Early Onset of Colon Cancer. Lancet. Vol 343, pg. 629. Key, Sandra W. and Marble, Michelle, 11/23/98, Study Finds Gene Marker Could Predict Colon Cancer. Cancer Weekly Plus, pg. 14, 2/3p. Goldinger, Michael. Colorectal Cancer- An Overview. The Colorectal Cancer Home page. Hochhauser, Daniel. 4/19/97, Colon Cancer Genotypes Change in Two Ways. Lancet, Vol. 349, pg. 1151. Newsweek, 12/13/93. Finding the Colon Cancer Gene. Vol. 122, pg. 72. Colon Cancer Essay -- Biology Biological Medical Essays Colon Cancer Disease Name: Colon Cancer Chromosome Number: #2 Locus Designation: 2p16 In the summer of 1993 researchers discovered a gene, known as MSH2, is lacking within colon cells. The MSH2 genes main function is to detect and correct small mutations that occur during cell division. The cause of colon cancer arises when this gene does not provide this protection to colon cells. This lack of protection causes multiple mutations within the colon cells until they become cancerous. Only about 6% of all colorectal cancer is said to be hereditary. Sporadic, or non hereditary colorectal cancer, makes up the other 94%. Hereditary colorectal cancer is made up of two syndromes- HNPCC (Hereditary Non Polyposis Colorectal Cancer) and FAP (Familial Adenomatous Polyposis). HNPCC is estimated to be 5% of the total hereditary colorectal cancer. HNPCC is a autosomal dominant disease, meaning that children have a 50% chance of inheriting the genetic trait from one of the parents being autosomally dominant. The parents who are autosomal dominant have a defect in their mis- match genes which identify and repair somatic mutations in DNA during cell division. Four genes have been identified as carrying this mutation; hMSH2, hMHL1, hPMS1, and hPMS2. ( h standing for hereditary) FAP constitutes only about 0.5 % of all hereditary colorectal cancer. It is also an autosomal dominant disease. Patients with FAP have a 100% risk of getting colorectal cancer, but it can be avoided. FAP is caused by a mutation in the APC gene on chromosome 5. The APC gene is able to be detected by a blood test. A study done in 1994 revealed that since the time the APC gene was identified 100 different mutations leading to st... ...er, making it the third leading cancer caused death rate. The main objective of doctors who deal with patients with colorectal cancer is not to cure, but actually to reduce mortality. With recent advancements research are finding new links to the effects of colorectal cancer genetically and physically. Works Cited: Caspari, Reiner. 3/12/94. Familial Adenomatous Polyposis: Mutations at Codon 1309 and Early Onset of Colon Cancer. Lancet. Vol 343, pg. 629. Key, Sandra W. and Marble, Michelle, 11/23/98, Study Finds Gene Marker Could Predict Colon Cancer. Cancer Weekly Plus, pg. 14, 2/3p. Goldinger, Michael. Colorectal Cancer- An Overview. The Colorectal Cancer Home page. Hochhauser, Daniel. 4/19/97, Colon Cancer Genotypes Change in Two Ways. Lancet, Vol. 349, pg. 1151. Newsweek, 12/13/93. Finding the Colon Cancer Gene. Vol. 122, pg. 72.

C20th Century Drama English Coursework Essay

This particular play is ‘A view from a Bridge’ written by Arthur Miller. Arthur Miller was born on October 17th, 1915, in New York City. His parents were both Illegal Immigrants in the United States, which links to the background of the play. A view from the Bridge was first produced as a one-act play in verse 1955; Arthur divorces his wife to marry his co-star actress Marilyn Monroe Miller has now become America’s world’s popular playwrights. Most of his plays are about the society and the responsibilities of its relation. But also in all the plays they hide a deep considerate of how people act and behave with the situation of life around them. These obstacles they face which they have to successfully defeat over. ‘A view from a Bridge’ has its roots in the late 1940’s when Miller was interested in the work and lives of New York. Miller purposely wanted the play to be a modern version of a Greek Tragedy, which a main character is faced with trying, daring situations, which cannot be escaped from. In this play a tragic hero commits an offence unexpectedly. He then learns from his misdeed and therefore must die for his actions. Then as it is a Greek Mythology the God’s restores the Universe. In this play the â€Å"Hero† is inked onto a man named Eddie Carbone. He is uniquely and ordinary everyday man. Courteous, hard working and a man that people liked. This play is themed on the background of Italian origins, which relates to the dispute of Italians and Americans. This is introduced with Alifieri’s Speech; â€Å"This is Red Hook not Sicily†¦ now we are civilised, quite American. Now we settle for half†¦. In no longer keep a pistol in my filling cabinet† This reflects with the context of the play and links with the storyline. It also reflects on the reason of the main cause concluding to the violence. The story is also based on the ‘American Dream’ that any person can accomplish what and no matter what upbringing culture or race. He has added this, as in that period of time the American Dream was quite popular which was appropriate for it to relate the aspects of their life. Arthur Miller has produced the main character being the lead role of the play. Eddie Carbone is an Italian Longshoreman working on the New York docks. Eddie is a simple hard workingman who worked on the piers. When his wife’s cousins were sent, Marco and Rodolfo, he agrees to refuge them as illegal immigrants from Sicily. First signs of disturbance are when Catherine starts to show attraction to Rodolfo, at this Eddie disapproves. This is because of Eddies over protectiveness towards Catherine. His possessive behaviour towards Catherine brings him to envy towards Rodolfo. Out of anger and rage at the end Eddie reported them to the Immigration Beaureu. In response of ferocity Marco decides to kill Eddie, but Eddie kills himself with the knife. In one section of evidence, which relates to his own downfall is the possessiveness of Catherine. Catherine is Eddie’s orphaned Niece. In the first scene the audience is immediately given the information that Eddie has a peculiar concern towards his niece. He mentions and details out of her dress sense and suggest it is too short. The evidence showing that he is overprotective is when he indicates that she is walking â€Å"wavy†. â€Å"I don’t like the looks they’re givin’ you in the candy store†¦ the heads are turnin’ like windmills. † In this it is brought immediately to the audience attention of the over protectiveness for his own nice. His concern and obssesiveness of his actions may have a hidden feelings that Eddie has for Catherine. An uncertainty of more than relative love is present with the way he feels for Catherine. Toe Eddie Catherine represents to him as â€Å"just a baby† and therefore she â€Å"does not understand these things† but this is a cover up for his possessive behaviour. In Act 1 page6-10 I suggest his behaviour is both possessive and protective but more possessive. As the conversation of Beatrice, Eddie and Catherine it shows that Eddie treats Catherine like a child, and not the rightful age that she should be treated. The relationship between Eddie and Catherine changes with the arrival of Marco and Rodolfo. As they talk and get to known each other Catherine shows an interest to Rodolfo as she keeps gesturing to Beatrice â€Å"He’s a real blond† He then sings to her â€Å"Paper Doll†, but in a kindest way Eddie tells him to stop. Also that is when the changes of Eddie’s behaviour begin. He embarrasses Catherine by telling her to ‘go ahead’ meaning get out. Eddie again tries to humiliate Catherine so that Rodolfo will lose interest by telling him that â€Å"she wants to be an actress† meaning she’s a drama queen. But Rodolfo flirts back by saying

Gender

What Is gender oscillation? (4 marks) 1. 2 using examples, explain how gender oscillation takes place wealth families? (6 marks) 1. 3 Identify and explain two possible problems that are a result of gender solicitation In the family. (4 marks) 1. 4 what strategies can be employed to redress problems relating to gender solicitation? (6 marks) Task 2- 4 typed pages, font 12, double spacing follow: I am the Girl Child by Antitank Cabala When I was born in Imbue, you tied twigs on my cot saying I would be a fetcher of firewood.When I was born in Inner, you said four ululations for me and five for my brother When I was born in Ethiopia, you said to give birth to a girl child was to bear a problem' When I was born in Zambia, you said ‘a girl is a peanut seed, she enlarges the clan' When I was born in Somalia, you told me that women are children with big feet When I was born in Nigeria, you told me that women were responsible for making the sky go higher and higher so that we cannot fe ed on it When I was born in Cameroon, you told me Women are half men' Finally, when I was born in BurningFast, you said When a woman praises you for climbing, she is praising you for your falling' My country, look at me! My continent, my father, my mother, my brother, my sisters too. 2. 1 Identify and explain the gender Issues In the poem (5 marks) 2. 2 What are the direct and indirect causes of African societies' negative perception of women as evidenced in the poem? (5 marks) 2. 3 How do such perceptions Influence the treatment of women and men In African societies? (5 marks) 2. 4 Give suggestions on what can be done to deconstruct such perceptions? (5 marks)

Night Mother by Kurt Vonnegut

Mother Night What intrigued me the most when reading Mother Night, by Kurt Vonnegut, were the quotes. He says things in a way that really make you step back and think. You could almost tell this book??? ‚a„? s story by discussing some of the quotes. In Mother Night, apolitical expatriate American playwright Howard W. Campbell, Jr. refashions himself as a Nazi propagandist in order to pass coded messages on to the U. S. generals and preserve his marriage to a German woman??? ‚aâ‚ ¬? their "nation of two," as he calls it. But in serving multiple masters, Campbell ends up ruining his life and becoming an unwitting inspiration to bigots. quot;We are what we pretend to be, so we must be careful about what we pretend to be. " Vonnegut introduces this as the moral of his book. "There are plenty of good reasons for fighting, but no good reason ever to hate without reservation, to imagine that God Almighty Himself hates with you, too. " It's never been more true: Left or right, Christian or Muslim, those convinced they're doing violence in service of a higher power and against an irretrievably inhuman enemy are the most dangerous creatures of all. But is Howard really such a bad man?All throughout reading the book, I would ask myself that question. No he doesn??? ‚a„? t seem to show much emotion, but doesn??? ‚a„? t that in a way seem understandable when you think about all he??? ‚a„? s done and seen? If he were to show emotion, he would go crazy. I know I would. Though he does seem to have a conscience, somehow, somewhere, deep down inside he is trapped. Trapped inside of the mess he??? ‚a„? s gotten himself into. I think he knows to that there is no way out, so he remains as this man he has pretended to be for so many years.Howard writes his story from a jail cell in old Jerusalem in 1961, while awaiting a fair trial for his war crimes by the republic of Israel. He is has a d ifferent guard for different parts of the day and night. One of them is Mengel. You are the only man I ever heard of,??? ‚N? Mengel says to me this morning, ??? ‚Nswho has a bad conscience about what he did in the war. Everybody else, no matter what he did, is sure a good man could not have acted in any other way.??? ‚N? ??? ‚NsWhat makes you think I have a bad conscience???? ‚N? I said. ??? ‚NsThe way you sleep, the way you dream,??? ‚N? e said. Howard tells Mengel about New York. ??? ‚Ns ??? ‚NsNew York must be Heaven,??? ‚N? said Mengel. ??? ‚NsIt might well be for you??? ‚N? , I said. ??? ‚NsIt was Hell for me,- or not Hell, something worse then Hell.??? ‚N? ??? ‚NsWhat could be worse then Hell???? ‚N? he said. ??? ‚NsPurgatory,??? ‚N? I said. ??? ‚Ns It??? ‚a„? s interesting that he says that, because that proves right there that Howard Campbell is very aware of the crimes he??? ‚a„? s committed, the difference between right and wrong, good and bad. He knows that he is there in that cell because he is paying the price.He must suffer for all that he has done. ??? ‚NsI was deposited on to the streets of New York, restored to the mainstream of life. I took several steps down the sidewalk when something happened. It was not guilt that froze me; I had taught myself never to feel guilt. It wasn't the fear of death; I had taught myself to think of death as a friend. It was not the thought of being unloved that froze me; I had taught myself to do without love. What froze me was the fact that I had absolutely no reason to move in any direction. What had made me move through so many dead and pointless years was curiosity.Now even that flickered out.??? ‚N? What a lonely life that must be, to feel you have nothing to live for. To know that all that has kept you going in the past was curiosity. Helga is dead, (or so he assumes) Resi is dead, the man he called his best friend had intentions of betraying him for so long, and now he is gone. People hate him, want to kill him, others think he is dead and are glad, and then there are those that admire him for all the terrible things he??? ‚a„? s done. Though he can??? ‚a„? t even seem to feel proud, because unlike so many others who committed such crimes as his, he is not a sociopath.

The role of stand up meetings in agile software development ( benefit) Essay

The role of stand up meetings in agile software development ( benefit) - Essay Example This study investigated one of the most important elements of the Agile approach, daily stand-up meetings. Over 40 percent of all the respondents were developers, the other bigger proportions were made up of project managers, analysts, software testers and solution architects. This can probably be attributed to the fact that in any process of software development, developers play the greatest role as they are directly involved in the technical processes. According to Martin (2003), an Agile development team needs sufficient software development personnel with deep experience and good working relationship to succeed. Project managers also formed a substantial proportion of all respondents; this too can be explained by the fact that every Agile team has got to be led by a project manager. Sometimes we have a larger project split into smaller project tasks each with a project manager (Larman, 2004). Other roles represented by respondents included Team Leads, Scrum Masters, CEOs, Testers , Delivery Managers, Agile coaches and Product owners. Many responses were not obtained from these groups, probably because they did not play huge roles in their team or they happened to be in leadership positions e.g. CEOs and Team Leads.The software development process function better at optimal conditions; this can only be made possible with the right number of members in a team, each playing a key role. Depending on the company and software development requirements of a project, Agile team sizes differ from project to another, Scrum and DSMD recommend that an ideal project team should have about 10 or twelve people. XP does not have a particular preferred number but recommends that teams be as small as possible. Over 83.8 percent of the respondents indicated that they worked in a team of between one and ten members - these are relatively small groups. Many software developers prefer to carry out projects in small flexible and manageable groups as recommended by the Agile methodo logy. Agile software development is particularly very iterative and participative and requires excellent communication, consultations and interaction between the members. For such teams to work effectively they require a moderate to minimum number of members for flexibility and greater team bonding, for example, stand-up meetings can be more effective and practical with fewer members in the team rather than a large number of members (Larman, 2004). A number of different Agile methods are used in software development. These include Scrum, DSDM, Extreme Programming, and Lean-Kanban. The choice of method is largely determined by software development needs as well as preference. According to Larman (2004), project needs sometimes dictate the choice of method between the various Agile methods. - Developer preferences also play a large part in determination of the methods to be adopted, in most cases once a method is adopted it is used by a company consistently for all other projects. Thi s study found that scrum is the most preferred Agile method with over 59 percent of the respondents using it. The popularity of scrum can be attributed to its ease of use and flexibility. According to Rising and Janoff (2000), Scrum remains the most

Histology Case Study Example | Topics and Well Written Essays - 750 words - 1

Histology - Case Study Example However, the epithelium does not contain any blood vessels. The native parenchyma has bloods in contrast to the invasive melanocytes tissue. The melanoma cells exhibits the features by rapid regeneration forming a pattern beneath the epithelium. The invasive tissue such as the carcinoma grow and break out of the bronchi structures and are not confined in the within the required acini structure of the lung, which possess a great danger as they can migrate to other human body parts or metastasize. The lung parenchyma is curbed within the bronchi structure and only grows and regenerates within the confined region of the bronchi. The characteristics of invasive tissue to grow out of the bronchi bock the airways hence are responsible for the tumor as they invade the adjoining tissue. Invasive tissue cause stellate arrangement of the cells in a spiral structure compared to the lung parenchyma tissue compactly arranged in rows. The case of the Caucasian woman in the case study requires more aspects in determining the cause of solitary lung metastasis after five years since the surgery of primary melanoma of the oesophagus Lung. Schueller and Herold spiral explains how the hamatogeneous spread is frequently found in tumors with venous drainage that is direct into the lung, which includes melanoma, testes, neck and head, adrenals, and osteosarcoma malignancies (126). The differential diagnosis of the lung metastases from this source indicates that patients initially known to have melanoma are frequently exposed solitary pulmonary nodule development later in life. Casciato affirms that the resection of a solitary Lung metastases in patients who fulfill the criteria of having history of Primary melanoma of the oesophagus (598). Keshamouni, Arenberg, and Kalemkerian emphasize on the question whether a tumor is primary or metastatic is of great significance for the

Biol Essay Example | Topics and Well Written Essays - 500 words

Biol - Essay Example (Lipstadt 27) Lipstadt is a well-known researcher and historian with a Ph.D. and the professor of Modern Jewish and Holocaust Studies at Emory University. (Alumni, Lipstadt Ph.D.) What Dawkins is discussing is the inevitable progression of people from belief to disbelief to outright lies in the attempt to ignore what we know is true. He later makes the statement that evolution is fact not a theory and that there is a difference between the fact that is evolution and the theory of its journey (Dawkins, Ph.D. FRS, FRSL) Clearly the purpose of this book is to first discredit attempts to disprove evolutionary theory while providing a basis for his approach. It is my opinion that he does a credible job in his approach In continued reading it becomes apparent to me that he has done his research and his proofs abound. His clear delineations between the â€Å"fact† as he calls it and the â€Å"theory† of what drives it tend to be very convincing.