The Need for More Medications for Dementia - 967 Words

Current medications for dementia are limited and there is a need to explore traditional medicinal system to investigate the agents that can prevent progression of memory loss or improve the existing capacity of learning and memory. Thus present study was carried out to evaluate the effects of Ayurveda drug formulations, Tinospora cordifolia (Tc) Phyllanthus emblica (Pe) with and without Ocimum sanctum (Os) on learning performance and memory of mice. We also tried to investigate the possible mechanisms of these plant drugs for their effects on learning and memory using Scopolamine, Diazepam and Cyclosporine as amnesic agents. Methods: After approval of Animal Ethics Committee, Swiss albino mice of either sex, and weight 18 to 25 grams were divided into 7 groups, administered orally either distilled water, Rivastigmine (2.4mg/kg), Tc (100mg/kg), Pe (300mg/kg), Formulation 1 (Tc+Pe: 400mg/kg) and Formulation 2 (Tc+Pe+Os:400mg/kg) daily for 15 days. Piracetam (200mg/kg) was injected daily intraperitoneally for 8 days. The mice underwent a learning session using Elevated Plus maze. Retention of learning (memory) was tested 24 hours later. Results: The mice pre-treated with modern as well as Ayurveda drugs showed trend towards reduction in transfer latencies but the values were statistically comparable to vehicle control. In the entire drug treated groups, a significant reduction (p0.05) was observed after 24 hrs in transfer latencies. Vehicle control did not show suchShow MoreRelatedThe Cognitive Effects Of Single Diagnosed With Dementia1642 Words   |  7 PagesDementia is a condition resulting from obtained brain disease and distinguished by progressive decay in memory and other cognitive fields such as judgment, abstract thinking, language, and executive functioning. This disease is usually caused by degeneration in the cerebral cortex, the part of the brain responsible for thoughts, memories, actions, and personality. 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